CELLULAR LOCALIZATION OF ANTI-DNP-PLL AND ANTICONVEYOR ALBUMIN ANTIBODIES IN GENETIC NONRESPONDER GUINEA PIGS IMMUNIZED WITH DNP-PLL ALBUMIN COMPLEXES
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چکیده
منابع مشابه
Cellular Localization of Anti-dnp-pll and Anticonveyor Albumin Antibodies in Genetic Nonresponder Guinea Pigs Immunized with Dnp-pll Albumin Complexes
Genetic nonresponder guinea pigs incapable of an immune response to DNP-PLL alone were immunized with DNP-PLL complexed to ovalbumin or bovine serum albumin. Under these circumstances the animals produce both anti-DNP-PLL antibodies and antibodies directed against the conveyor albumin. Thus immune response to DNP-PLL complexed to conveyor albumin molecules can serve as a simple model of hapten-...
متن کاملHapten-carrier relationships.
The ability of guinea pigs to recognize poly-I,-lysine (PLL), and hapten conjugates of PLL (H-PLL) as antigens is under the control of a single autosomal dominant gene which we will refer to as the PLL gene (1-3). Responder animals carrying this gene form specific antihapten antibodies and display delayed hypersensitivity reactions after immunization with H-PLL conjugates such as 2,4-dinitrophe...
متن کاملTHE EFFECT oF GRAFT-VERsus-HosT REACTION ON THE ANTIBODY RESPONSE TO POLY-L(TYR, GLu)-POLY-D ,L-ALA--POLY-L-LYs IN NONRESPONDER MICE* BY JOHN C. ORDAL~ AND F. CARL GRUMET§
The immune response of mice to the branched multichain synthetic polypeptide poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys [(T,G)-A--L] I is under the control of a cedominant gene, I tl , which maps near the middle of the major histocompatibillty (11-2) complex (1). H-2 bib mice given a primary challenge of (T, G)-A--L in adjuvant and a secondary challenge of (T, G)-A--L in saline produce large amou...
متن کاملHapten Carrier Relationships in the Dnp-pll·foreign Albumin Complex System: Induction of Tolerance and Stimulation of Cells in Vitro
Genetic nonresponder guinea pigs made tolerant to BSA and then immunized with DNP-PLL.BSA failed to make anti-DNP-PLL antibodies. Thus, tolerance to a carrier protein renders animals unresponsive to the hapten which it bears. The addition in vitro of DNP-PLL or DNP-GL to lymph node cell cultures derived from genetic responder animals immunized with these materials led to a significant stimulati...
متن کاملThe Behavior of Hapten-poly-l-lysine Conjugates as Complete Antigens in Genetic Responder and as Haptens in Nonresponder Guinea Pigs
30 to 40% of Hartley strain guinea pigs have previously been demonstrated to possess a dominant autosomal gene which enables them to recognize the antigenicity of hapten-poly-L-lysine conjugates as expressed by the development of both antihapten antibodies and delayed hypersensitivity to the immunizing antigen. In the present study, it was shown that PLL alone was weakly antigenic in such genet...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1967
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.125.3.527